منابع مشابه
Translation termination and yeast prions.
Protein biosynthesis is the final step in the transfer of genetic information in the cell. In turn, its last step is the release of a nascent polypeptide from the ribosome. Therefore, termination of translation may be considered (if we do not take into account protein post-translational modification and folding) as a final step of the transition from genotype to phenotype through the classic DN...
متن کاملEmerging Understanding of Translation Termination
The existence of a protein with RF activity in eukaryThe termination of protein synthesis takes place on the otes was demonstrated some twenty years ago in rabbit ribosomes as a response to a stop, rather than a sense reticulocytes (Konecki et al., 1977). After two decades codon in the ’decoding’ site (A site). Translation terminaof investigation, a eukaryotic protein family with the tion requi...
متن کاملCompetition between trans-translation and termination or elongation of translation
The effects of tRNA, RF1 and RRF on trans-translation by tmRNA were examined using a stalled complex of ribosome prepared using a synthetic mRNA and pure Escherichia coli translation factors. No endoribonucleolytic cleavage of mRNA around the A site was found in the stalled ribosome and was required for the tmRNA action. When the A site was occupied by a stop codon, alanyl-tmRNA competed with R...
متن کاملMimicry Grasps Reality in Translation Termination
only UAA while the Ser-Pro-Thr variant recognizes three stop codons and UGG as well. They are referred to as a tripeptide “anticodon” that deciphers stop codons in Yoshikazu Nakamura,*‡ Koichi Ito,* and Måns Ehrenberg† *Department of Tumor Biology The Institute of Medical Science mRNA. The University of Tokyo Pauling’s Paradox and the Release Factor Solution Minato-ku, Tokyo 108-8639 In additio...
متن کاملTranslation termination: new factors and insights.
In eukaryotes, translation termination requires two eukaryotic release factors, eRF1 and eRF3. eRF1 is required for recognition of the stop codon and eRF3 supports the polypeptide chain release in a GTP dependent manner. Recently, several new players in translation termination have been identified. The DEAD-box RNA helicase Dbp5 has been shown to support eRF1 in stop codon recognition, possibly...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2001
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(01)00368-9